Relação entre pressão intra-selar e volume de tumor de hipófise

Jackson A. Gondim^I; Osvaldo I. Tella Jr.^II; Michele Schops^III

^INeurosurgery Department General Hospital of Fortaleza, Fortaleza CE, Brazil
^IINeurosurgery Service, Federal University of São Paulo, São Paulo SP, Brazil
^IIIFederal University of Ceará, Fortaleza CE, Brazil

ABSTRACT

OBJECTIVE: To determine if there was a relationship between intrassellar pressure (ISP) and pituitary tumor volume.
METHOD: Between August 2002 and May 2004, 60 patients aged between 13 and 75 years old (39 males), having a pituitary adenoma were submitted to an endoscope transseptal approach. During the surgery and before tumor resection, 2 mm of the sellas floor were removed and a 1.5 mm dural opening made to place a transducer into the pituitary adenoma. The transducer was connected to a pressure monitor.
RESULTS: The intrasellar pressure, ranged from 2-51 mmHg and was measured based on the classification of Hardy-Vezina. The most elevated was in the type II macro adenomas with 32.6 mmHg, sharply superior to the value of a normal intracranial pressure.
CONCLUSION: These values showed that the macroadenomas confined to the sella, without destruction of the floor and integrity of the diaphragm, type II of Hardy-Vezina, presented a value of ISP much higher than intra-extrasellar macroadenomas.

Key words: pituitary adenoma, intrasellar pressure, endonasal approach

RESUMO

OBJETIVO: Determinar se existia uma relação entre a pressão intraselar (ISP) e o volume de tumor de hipófise.
MÉTODO: Entre agosto de 2002 e maio de 2004, 60 pacientes com idades variando entre 13 e 75 anos (39 homens), portadores de adenoma hipofisários foram operados por via transesfenoidal. Durante o ato cirúrgico e antes da resseção do tumor, uma osteotomia de 2 mm foi realizada no assoalho selar e uma abertura de 1,5 mm na duramater para a introdução de um transdutor dentro do tumor. O transdutor foi conectado a um monitor de pressão e esta foi medida por 2 minutos.
RESULTADOS: A pressão intra-selar variou entre 2-51 mmHg e a correlação entre tamanho do tumor e ISP foi baseada na classificação de Hardy-Vezina. A média da ISP mais elevada foi encontrada nos macroadenomas tipo II com 32,6 mmHg, nitidamente superior a pressão intra selar normal.
CONCLUSÃO: Estes valores mostram que os macroadenomas confinados a sela sem destruição do assoalho selar e com integridade do diafragma, classificados como tipo II de Hardy-Vezina, apresentam uma ISP muito superior aos outros adenomas.

Palavras-chave: adenoma hipofisário, pressão intra-selar, via transesfenoidal.

There are studies in the literature correlating intrasellar pressure (ISP) and adenoma blood flow¹, ISP and stalk compression syndrome², ISP and endocrine function^3,4, ISP and headaches³, pituitary volume and headache⁵, ISP and pituitary tumor apoplexy⁶, but there are no specific studies correlating ISP and tumor volume.

The walls of the sella turcica are a relatively rigid structure and under normal circumstances, may serve to protect the pituitary gland from trauma and surrounding pressure fluctuations. The growth of a tumor within the sella, a normally inelastic space, is likely to cause an increase of ISP. It has been conjectured that relatively small increases of ISP may disturb anterior pituitary perfusion and endocrine function because of the low input pressure of the feeding portal veins³. Normal ISP is not known but it is unlikely to exceed normal intracranial pressure (ICP). The ISP has been shown to be elevated in patients with pituitary tumors³. It has been proposed that relatively small increases of ISP may disturb anterior pituitary perfusion. The highest pressures were recorded in tumors with parasellar invasion irrespective of the size and extension and there were no correlation between the level of raised ISP and the tumors size³. Our study, in the contrary, postulates that the highest ISP is found in macroadenomas confined to an enlarged sella without disruption of the floor and with integrity of the diaphragm as type II tumor of Hardy Vezina⁶.

The objective of this study is to determine if there is a relationship between ISP and pituitary tumor volume.

METHOD

Between August 2002 and May 2004 sixty consecutive patients (39 males) with pituitary adenomas were operated by transnasal transsphenoidal endoscopic surgery and had their ISP measured during surgery for pituitary adenoma at our institution. Their age was between 13 and 75 years old. Among the 60 cases, studied, 42 (70%) were functional adenomas (eighteen producing adrenocorticotropin hormone, fourteen producing growth hormone, six producing prolactine hormone and four cases of plurihormonal adenomas) and eighteen null cells adenomas. All patients were ambulatory. No patients were using glucocorticoids or had pituitary apoplexy, but some patients had adenomas with cystic component. The patients with hormonal hypopituitarism, the compensation usually begins in the transoperative period. The study was approved by the Institutional Review Board of General Hospital of Fortaleza, an informed consent was obtained from each patient.

All patients underwent pituitary computerized tomography (CT) and magnetic resonance image (MRI) at 1.5 T. The MRI examination included coronal and sagittal T1-weighted spin-eco sequences with a maximum section thickness of 3 mm, before and after intravenous administration of a gadolinium-based contrast medium. For the estimation of the tumor volume, it was assumed that the pituitary tumors had an ellipsoid form^5,7-9. If the tumor was large and multilobed, the tumor volume was assumed to consist of separated ellipses and the sum of each volume was calculated.

Tumors were subdivided according to radiological classifications of Hardy and Vezina⁶. The tumors were classified as microadenoma grade 0 where they weren’t visible on imaging. Immunohistochemical characteristics of tumor were available in all patients.

Pre-operative pituitary function evaluation was performed in all patients, and included basal serum free T4, free T3, thyroid stimulation hormone, follicle-stimulating hormone, luteinizing hormone, testosterone (men), cortisol levels on multiple days, adrenocorticotropic hormone, prolactin, growth hormone and somatomedin-C and a glucose tolerance test with GH.

The transsphenoidal exploration was carried out under general anesthesia with normotension and normocapnia. The pituitary sellas floor was exposed through a transnasal transseptal approach assisted by endoscope¹⁰. On entering the sphenoid air sinus a 2-mm diameter window of the bone sellas floor was remove and a 1.5 mm dural opening was made to allow the transducer placed into a needle in the tumor mass without extravasation of intrasellar content. Once the transducer placed the needle is taken off and the ISP measured. In some patients with cystic component a careful attention is made for extravasations of tumor component. If there were tumor component extravasations, the ISP measurement would be stopped and the patient wouldn’t count. The fiberoptic transducer is located at the tip and has a 1.3 mm diameter. Sixty seconds later, after a stable pressure obtained, the pressure was recorded, the transducer removed and the tumor resection initiated. We used the Coodman Intracranial Pressure Monitoring Kit (Camino Laboratories San Diego, CA) to determinate the ISP. The kit uses a fiberoptic transducer connected to a pressure monitor.

The statistic analysis was done using the test of Levene to see the homogeneity of variances. The F test was done to know if there was a difference between the five intrasellar pressure median groups. The individual comparisons between the pairs of the five group of ISP were done using the multiple comparasions test of Bonferroni. Statistic analysis using the F test was done with the prolactine medium in each group of patients (Cushing, acromegaly and null cells adenoma). The ISP was also compared into the four group of pathology (acromegaly, Cushing, prolactinoma and nulls cells adenoma). Variables with significant probability values (p<0.05) were considered a possible significant. Statistical evaluation was performed with commercially available statistical software (SPSS version 10.0).

RESULTS

Tumor volume was measured in all adenomas and varied between 0 cm³ (in six patient with clinical and laboratorial diagnosis of Cushing’s disease, but with no radiological image) and 134.5 cm³ in a non-functioning pituitary adenoma with a cystic component. The tumors of this series were solid in 51 patients (85%) and had a cystic component in 9 (15%).

The ISP was measured in all 60 patients and ranged from 2-51 mmHg with mean (±sd) of 18.7±10.8 and a median of 16 mmHg. The test of homogeneity of variances Levene Statistic showed significant (1.639 p=0.178) the amostrage of ISP measurement. The median comparison of the five groups of ISP showed all different (F 17.69 p=0.001). The statistic study was done to known the specific pair-wise analyses and showed that ISP of group 2 of Hardy-Vezina was different in the pair comparison of all other group (0 an2 p=0.026; 1 and 2 p=0.0001, 2 and 3 p=0.0001; 2 and 4 p=0.0001).

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